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Functions
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Folate is a building block of DNA and RNA (genetic material). It assists in the formation of heme. Needed for normal maturation of all cells. Folate is required in periods of accelerated growth, and is depleted by alcohol or drug abuse.
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Uses
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Megaloblastic anemia; orofacial cleft and NTD prevention taken during pregnancy; restless leg syndrome; cervical dysplasia; depression (esp. epileptics); malabsorption; GI inflammation. Likely preventive to heart disease. May be useful in mood disorders. |
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Deficiency
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Folate deficiency is the most common deficiency in the world. Folate deficiencies
may lead to neural tube defects. It can be cause by oral contraceptive use, some
anti- Deficiency may result in poor growth; blood disorders; megaloblastic anemia; glossitis; GI problems; epithelial cells are most affected; pain sensitivity; graying hair; dec resistance to infection; ulcers; low WBC counts; premature births; neural tube defects; poor memory.
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Antagonists |
May interfere with anti- |
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Co-
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Absorbed from the small intestine. Folate requires vitamin B12, niacin and vitamin C. |
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Drug Interactions
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None known.
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Dose
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RDA: 400 mcg male; 400mg female, 600 mcg/500 mcg pregnant/lactating Therapeutic: (ther: 800mcg-
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Toxicity
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None known (masks neurological and gastrointestinal symptoms of pernicious anemia) |
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Sources
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Folate is found in:
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